Application of proteomics in biological and biotechnological research

Our research enables a wide range of applications across diverse biological fields, allowing proteomics to be applied to various scientific questions, including general, physiological, environmental, and infection-related microbiology. Therefore, our methods are applied in multiple studies, for example:

Biology of infection and stress physiology

The rapid adaptation of pathogenic microorganisms to host immune defenses and new antimicrobial therapies necessitates the development of novel therapeutic strategies to combat bacterial infections. Achieving this requires a deeper understanding of the mechanisms underlying bacterial adaptation. We are involved in numerous physiological studies that use comparative protein expression analyses to provide improved qualitative insights into these adaptive networks. Some examples include:

Environmental Metaproteomics

Fascinating biological processes occur throughout natural environments that could not be fully explored with pre-proteomics methodologies. This applies, for example, to dynamic coastal regions, marine and terrestrial soils, microbial mats, and highly complex microbiomes such as those found in the human gut or the rumen. While genomics and transcriptomics describe the potential and activity of microorganisms, metaproteomics provides access to the functional level. By analyzing proteins as the actual mediators of metabolism, we gain insight into the processes that are actively taking place within a microbial community.